Blood Biomarkers Based Screening for HPV-driven OPC

Starting soon · Not applicable

Conditions studied: Head and Neck Squamous Cell Carcinoma, Anal Cancer, Human Papilloma Virus

In brief

The objective of our study is to demonstrate that it is possible to detect and treat human papilloma virus (HPV)-related oropharyngeal cancers (OPC) early using simple blood tests. The success of this strategy will be evaluated by the number of participants positive for both HPV16-E6 serology and HPV circulating tumor DNA (ctDNA) whose early management has allowed the detection of a cancerous lesion and/or whose HPV ctDNA results have normalized after surgical intervention. If this study is conclusive, it could pave the way for the implementation of a national screening strategy for HPV-related OPC.

Key facts

Study ID

NCT06528353

Run by

UNICANCER

People needed

10000

Starts

2026-09-01

Expected to finish

2032-09-01

Last updated by the study team

2026-05-26

Who can join

Age: 50 and older. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Aged ≥50 years from the general population
• Man
• No previous history of HPV-driven cancer or head neck cancer
• Willingness to complete follow up visits

You may not qualify if…

• Aged < 50 years
• Woman
• History of HPV-driven cancer or head and neck cancer
• Psychiatric conditions
• Inability to complete follow up visits
• Severe medical condition (life expectancy <5 years)
• Previous prophylactic HPV vaccination

Full record on ClinicalTrials.gov

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