Clinical Characteristics and Prognosis of Acute Stroke in Pregnancy and Puerperium
Recruiting now
Conditions studied: Pregnancy-associated or Puerperium-associated Acute Stroke
In brief
The objectives of this study are: (1) to describe the detailed clinical characteristics and prognosis of ASPP patients in order to explore the risk factors of ASPP, and to compare the short-term and long-term functional recovery outcomes between them and their controls; (2) to evaluate the risk of recurrent stroke, particularly during subsequent pregnancies, in ASPP patients; (3) to assess the short-term and long-term outcomes of their offsprings and their future development status. This study is divided into three parts. The first part is a case-control study to explore the risk factors of ASPP and the predictors of the prognosis of ASPP patients. The second part is a cohort study to evaluate the impact of ASPP on the risk of recurrent stroke. The third part is a cohort study to assess the impact of ASPP on the short-term and long-term outcomes of their offsprings by comparing the offsprings of ASPP patients with the offsprings of non-ASPP participants.
Key facts
- Study ID
- NCT06527807
- Run by
- Beijing Tiantan Hospital
- People needed
- 1200
- Starts
- 2024-07-31
- Expected to finish
- 2025-06-01
- Last updated by the study team
- 2024-08-07
Who can join
Age: any. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Female patients ≥18 years of age;
- Patients or their legally acceptable representatives or relatives agree to collect personal information for this study and sign an oral or online written informed consent.
You may not qualify if…
- Patients or their legally acceptable representatives or relatives refuse follow-up;
- Patients missing critical baseline demographic, clinical or neuroimaging data.
- Cohort Study on Offspring Outcomes:
- Inclusion Criteria:
- Female patients ≥18 years of age;
- Patients in pregnancy or within 6 weeks postpartum;
- Patients or their legally acceptable representatives or relatives agree to collect personal information for this study and sign an oral or online written informed consent.
- Exclusion Criteria:
- Patients or their legally acceptable representatives or relatives refuse follow-up;
- Patients missing critical baseline demographic, clinical or neuroimaging data;
- Patients whose offsprings have congenital malformation or inborn error of metabolism;
- Patients with complications which may affect cerebral blood flow supply, such as amniotic fluid embolism, in pregnancy;
- Patients whose family members other than the parents and siblings of their offsprings have a history of severe mental illness, such as mental retardation, autism and schizophrenia;
- Patients undergo acute myocardial infarction in pregnancy;
- Patients undergo non-spontaneous stroke events due to other causes, such as cerebral infarction or hemorrhage caused by surgery.
Where it is running
- Beijing Tiantan hospital — Beijing, Beijing Municipality, China (enrolling)
Full record on ClinicalTrials.gov
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