Inspiratory Effort-Targeted Pressure Support Ventilation (IT-PSV) Trial
Recruiting now · Not applicable
Conditions studied: Critical Care, Acute Hypoxic Respiratory Failure, Ventilator-Induced Lung Injury
In brief
The Inspiratory effort-Targeted Pressure Support Ventilation (IT-PSV) is a cluster randomized controlled trial. Its main aim is to determine whether an inspiratory effort-targeted pressure support setting strategy, compared to the traditional tidal volume and respiratory rate target, can improve clinical outcomes in adult participants undergoing pressure support ventilation. The investigators propose a physiological-oriented assisted ventilation management that, if found effective, could potentially change the clinical practice for mechanical ventilation.
Key facts
- Study ID
- NCT06526598
- Run by
- Capital Medical University
- People needed
- 619
- Starts
- 2026-01-19
- Expected to finish
- 2027-02-28
- Last updated by the study team
- 2026-01-21
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- PSV initiated during the last 24 hours;
- Mechanical ventilation expected to be required for at least 24-48 h by responsible physicians;
- The partial pressure of oxygen in arterial blood (PaO2)/inspired oxygen fraction (FiO2) ≤ 300 mmHg (measuring at clinical FiO2 and positive end-expiratory pressure PEEP);
- No sedation or stable sedation with Richmond Agitation Sedation Scale (RASS) of -2 to +1 or Riker's Sedation-Agitation Scale (SAS) of 3 to 4.
- Exclusion criteria included:
- Age younger than 18 years old;
- Initiation of PSV before ICU admission;
- Duration of mechanical ventilation longer than 7 days before enrollment;
- History of neuromuscular diseases;
- Clinical suspicion of increased intracranial pressure;
- Extracorporeal support;
- Moribund conditions;
- Refusal by the ICU physicians or the patient.
Where it is running
- Beijing Shijitan Hospital — Beijing, Beijing Municipality, China (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.