Acute Intermittent Hypoxia to Improve Airway Protection in Chronic Traumatic Brain Injury

Completed · Not applicable · Has a placebo group

Conditions studied: Traumatic Brain Injury

In brief

Acute intermittent hypoxia (AIH) involves 1-2min of breathing low oxygen air to stimulate neuroplasticity. Animal and human studies show that AIH improves motor function after neural injury, particularly when paired with task-specific training. Using a double blind cross-over study we will test whether AIH and task-specific airway protection training improves airway protection more than training alone in individuals with chronic mild-moderate traumatic brain injury (TBI).

Key facts

Study ID

NCT06520358

Run by

University of Florida

People needed

5

Starts

2024-08-30

Expected to finish

2025-09-30

Last updated by the study team

2026-01-09

Who can join

Age: 21 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 21-80 years
• A mild to moderate traumatic brain injury (TBI) confirmed by medical records
• A Glasgow Coma Scale score between 9-15
• Able to consent independently
• Women of child-bearing age must be comfortable confirming a negative pregnancy prior to participating in the study

You may not qualify if…

• Other neurological diagnoses or a diagnosis of a severe psychiatric disorder
• Severe aphasia preventing a participant from understanding the protocol and consent form
• Pre-existing hypoxic pulmonary disease
• History of obstructive lung diseases such as chronic obstructive pulmonary disease (COPD) or significant asthma)
• Severe hypertension (>160/100)
• History of head and neck cancer
• Allergy to barium sulfate
• Ischemic cardiac disease

Where it is running

• University of Florida — Jacksonville, Florida, United States

Full record on ClinicalTrials.gov

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