Exercise, Brain Activity, and Weight Maintenance

Recruiting now · Not applicable

Conditions studied: Obesity, Weight Gain, Bariatric Surgery Candidate, Appetitive Behavior

In brief

This study aims to explore how HIIT influences brain function, neural and molecular pathways related to weight control, setting the stage for future obesity intervention research.

Key facts

Study ID

NCT06511310

Run by

Joslin Diabetes Center

People needed

15

Starts

2025-09-15

Expected to finish

2027-07-01

Last updated by the study team

2025-09-04

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18-70 years
• Body mass index (BMI) >19 kg/m2 and body weight< 250kg
• Participants must have experienced a clinically significant weight regain, defined as over 10% of their maximum weight lost, within 1 to 5 years following their bariatric surgery. They will be asked to self-report their weight loss history. Participants must also provide the operative report from their bariatric surgery for reference.
• In good general health with no conditions that could influence the outcome of the trial, and in the judgment of the investigator is a good candidate for the study based on review of available medical history, physical examination and clinical laboratory evaluations
• Willing to adhere to the protocol requirements for the duration of the study

You may not qualify if…

• Type 1 diabetes mellitus
• Peripheral neuropathy with insensate feet
• Recent blood donation within the last 2 months
• Use of beta-blockers
• Current pregnancy or breastfeeding
• Active Heart or lung disease
• Severe hypertension (systolic >160 mmHg or diastolic >90 mmHg)
• Inability to exercise for any reason
• Any known contraindication to exercise testing based on current ACSM guidelines
• MRI contraindications, such as presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin, or body
• Known presence of a structural brain lesion (e.g. tumor, cortical infarct)
• Presence of another neurologic disorder, which could impact findings (e.g. multiple sclerosis)
• History of cardiovascular disease, stroke, congestive heart failure
• Active hematological, renal, pulmonary or hepatic disorders
• Active treatment for cancer
• A history of active alcohol or substance abuse
• Any significant systemic illness or unstable medical condition which could lead to difficulty complying with the study protocol
• History of claustrophobia and inability to tolerate an MRI
• Body weight >250kgr and largest body diameter of 70cm as there is a certain weight and diameter limit of the MRI scanner
• Unwilling or unable to return for study visits, undergo neuropsychological testing and MRI imaging
• Left-handedness

Where it is running

• Joslin Diabetes Center — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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