Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction

Recruiting now · Phase 4

Conditions studied: Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture

In brief

The purpose of this study is to determine if intraosseous (IO) morphine decreases pain and post-operative opioid use in patients undergoing anterior cruciate ligament (ACL) reconstruction.

Key facts

Study ID

NCT06511232

Run by

The Methodist Hospital Research Institute

People needed

84

Starts

2024-08-19

Expected to finish

2029-07-31

Last updated by the study team

2026-04-09

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients of the IRB approved surgeon(s) undergoing ACL reconstruction with bone-to-bone (BTB) autograft
• Patients aged between 18-40 years old at the time of surgery

You may not qualify if…

• Patients undergoing ACL reconstruction with any other type of autograft or allograft other than BTB
• Patients younger than 18 years old or older than 40 years old
• Patients undergoing meniscal root repair or any other repair that changes their weight-bearing status
• Patients with a history of substance abuse
• Vulnerable populations
• Patients on chronic pain medication within the last 6 months
• BMI >/= 35
• Allergy to morphine
• Unwilling to participate
• Any additional reason the PI deems reasonable

Where it is running

• Houston Methodist Research Institute — Houston, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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