A Study Investigating the Efficacy and Safety of Intravitreal (IVT) Injections of Vonaprument (Formerly ANX007) in Participants With Dry Age-Related Macular Degeneration (AMD) With Geographic Atrophy (GA)

Running, not enrolling · Phase 3 · Has a placebo group

Conditions studied: Geographic Atrophy

In brief

The primary purpose of the study is to determine if IVT injections of vonaprument every month reduce vision loss in participants with dry AMD with GA.

Key facts

Study ID

NCT06510816

Run by

Annexon, Inc.

People needed

659

Starts

2024-07-30

Expected to finish

2027-07-31

Last updated by the study team

2026-05-04

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of dry AMD with GA as determined by the Investigator and confirmed by the independent Central Reading Center.

You may not qualify if…

• Geographic atrophy due to other causes than AMD such as Stargardt disease, cone-rod dystrophy, pathologic myopia, or toxic maculopathies (for example, plaquenil maculopathy) in either eye.
• NOTE: Other protocol-defined inclusion and exclusion criteria apply.

Where it is running

• Retina-Vitreous Associates Medical Group — Beverly Hills, California, United States
• Retinal Consultants of Orange County Clinical Research Institute Inc — Fullerton, California, United States
• Global Research Management — Glendale, California, United States
• Retina Consultants Medical Group — Modesto, California, United States
• Northern California Retina Vitreous Associates Medical Group, Inc. — Mountain View, California, United States
• Retinal Consultants Medical Group — Sacramento, California, United States
• Macula Retina Vitreous Research Institute — Torrance, California, United States
• Bay Area Retina Associates — Walnut Creek, California, United States
• Retina Consultants of Southern Colorado PC — Colorado Springs, Colorado, United States
• RSC Research, LLC — Denver, Colorado, United States
• Rand Eye Institute — Deerfield Beach, Florida, United States
• National Ophthalmic Research Institute — Fort Myers, Florida, United States
• Florida Retina Institute — Orlando, Florida, United States
• Fort Lauderdale Eye Institute — Plantation, Florida, United States
• Retina Group of Florida — Sarasota, Florida, United States
• Retina Vitreous Associates of Florida — St. Petersburg, Florida, United States
• East Florida Eye Institute — Stuart, Florida, United States
• Retina Associates of Florida — Tampa, Florida, United States
• Georgia Retina PC — Marietta, Georgia, United States
• Retina Consultants of Hawaii — ‘Aiea, Hawaii, United States
• Retina Associates Ltd — Elmhurst, Illinois, United States
• University Retina — Oak Forest, Illinois, United States
• Springfield Clinic LLP — Springfield, Illinois, United States
• Wolfe Eye Clinic — West Des Moines, Iowa, United States
• Retina Macula Institute of Arizona — Scottsdale, Arizona, United States

Full record on ClinicalTrials.gov

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