Chronic Subdural Hematoma Treatment With Intra-Arterial Bevacizumab Injection

Recruiting now · Phase 1/Phase 2

Conditions studied: Chronic Subdural Hematoma

In brief

The goal of this clinical trial is to test whether infusing bevacizumab into the middle meningeal arteries can be used to treat chronic subdural hematomas (cSDH). The main questions it aims to answer are: * Is bevacizumab infusion safe in cSDH patients? * Is bevacizumab infusion effective in treating cSDH?

Key facts

Study ID: NCT06510582
Run by: The Cooper Health System
People needed: 140
Starts: 2024-06-17
Expected to finish: 2028-06-01
Last updated by the study team: 2025-07-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Adult patients (≥18 years)
Radiographic evidence of chronic subdural hematoma, including
Persistence of subdural blood more than 10 days after index traumatic injury or event
Presence of mixed density blood
Presence of subdural membranes
Can obtain informed consent and Health Insurance Portability and Accountability Act (HIPAA) authorization.

You may not qualify if…

Pregnant, breastfeeding, or unwilling to practice contraception during participation in the study.
Patients with concomitant intracranial pathology other than subdural hematoma (e.g., intracranial malignancy).
Patients with known hypersensitivity to bevacizumab.
Patients with radiographic evidence of mass effect.
Patients have focal neurological deficits attributed to subdural hematoma.
Patient had craniotomy or burr hole operative procedures performed in preceding two weeks prior to onset of subdural hematoma.
Secondary causes apart from trauma for the chronic subdural hematoma, such as underlying vascular abnormality or tumor.
Emergent surgical evacuation is required for the patient.
Non-convexity chronic subdural hematoma, as the middle meningeal artery will not supply this area.
Coagulation abnormalities, including platelet count <100,000 and/or international normalized ratio of <1.5 despite attempts for correction.
Patients with known contraindications for angiography. Patients with contrast allergy will be premedicated with diphenhydramine and steroids.
Patient has known active systemic infection or sepsis.
Patient has contradiction to anesthetic agents used for conscious sedation/monitored anesthesia care (MAC).
Patient has life expectancy of less than six months due to comorbid terminal conditions.
Patient has a premorbid modified Rankin score (mRS) of 5 or greater.
Concurrent participation in another research protocol for investigation of an experimental therapy.

Where it is running

Cooper University Health Care — Camden, New Jersey, United States (enrolling)

Full record on ClinicalTrials.gov

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