Methacholine Challenge Test (MCT) in Healthy Adults

Recruiting now

Conditions studied: Hyperreactive Airway Disease

In brief

Knowledge of Methacholine Challenge Test (MCT) and impedance Oscillometry (IOS) is limited. Only three studies have included adult patients, and none of these with healthy controls. The three studies have combined IOS and spirometry in the same test, although it is not recommended to perform IOS after a test that requires deep breathing, e.g. FEV1 measurement. Deep breathing is considered to affect the impedance via reduced tone in the smooth muscle.

Key facts

Study ID

NCT06509659

Run by

Allergi- og Lungeklinikken, Elsinore

People needed

25

Starts

2024-08-10

Expected to finish

2024-12-23

Last updated by the study team

2024-09-19

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Forced expiratory volume in the 1. second (FEV1) >80%
• FEV1/FVC-ratio >0,7
• FeNO <25 pbb
• Oxygen saturation (SatO2) >95%
• Negative methacholine Challenge Test = drop in FEV1 less than 20%

You may not qualify if…

• Any lung disease
• Lung symptoms
• Medicine for lung disease
• Tobacco smoking
• Ex-smokers with more than 5 package years
• BMI (body mass index) >40 kg/m2

Where it is running

• Thomas Ringbæk — Elsinore, Denmark (enrolling)

Full record on ClinicalTrials.gov

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