Pancreatitis - Microbiome as Predictor of Severity II

Recruiting now

Conditions studied: Acute Pancreatitis, Acute Pancreatitis With Infected Necrosis

In brief

The goal of this observational study is to evaluate the orointestinal microbiome and microbial derived metabolome in patients suffering from acute pancreatitis as a biomarker for severity. The main questions it aims to answer are: * Can the orointestinal microbiome robustly predict the course of acute pancreatitis? * How does the microbiome impact the severity of an acute pancreatitis? Buccal/ rectal swabs, plasma and stool is collected from patients with acute pancreatitis within 48h after hospital admission.

Key facts

Study ID

NCT06508502

Run by

University Medical Center Goettingen

People needed

700

Starts

2024-05-01

Expected to finish

2027-12-31

Last updated by the study team

2025-07-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with initial diagnosis (< 48h) of acute pancreatitis
• Age ≥ 18 years
• Patients able to understand/ give their written consent

You may not qualify if…

• Recurrent acute pancreatitis (>2 previous episodes)
• Clinical or imaging signs of chronic pancreatitis
• Referred patients with length of hospital stay > 48h

Where it is running

• University Medical Center Goettingen — Göttingen, Lower Saxony, Germany (enrolling)

Full record on ClinicalTrials.gov

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