Concordance and Acceptability of Self-screening Versus Screening by a Healthcare Professional for HPV, a Risk Factor for Anal Cancer, by Swab in People Living With HIV

Recruiting now · Not applicable

Conditions studied: HPV Infection

In brief

Anal canal cancers are on the increase in France, with around 2,000 new cases per year. These lesions can be detected by directed biopsies or smear tests. The incidence rate of anal cancer is 30 times higher in people living with HIV than in the general population. According to a recent study, the risk of anal cancer is highest in this population, but is also high in heterosexual men over 30 and women over 30. However, the proposal of a proctological examination in this population is not systematic. In France, there is no HPV screening for people living with HIV, but there is a recommendation for proctology consultation in certain cases, notably for men who have sex with men (MSM) or for women with vaginal cervical lesions. Several oncogenic HPV serotypes have been identified in the genesis of anal cancer. The serotype identified as the most carcinogenic is HPV-16 (89%). This study will look at anal HPV screening in people over 30 living with HIV, thus including a population for which no screening is currently offered (heterosexual men living with HIV and women living with HIV without vaginal cervical lesions), and will assess the concordance and acceptability of self-screening versus screening by a healthcare professional as part of a comprehensive anal cancer screening strategy in this population.

Key facts

Study ID

NCT06507917

Run by

Centre Hospitalier Universitaire de la Réunion

People needed

398

Starts

2025-11-28

Expected to finish

2027-01-02

Last updated by the study team

2025-12-11

Who can join

Age: 30 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient :
• living with HIV
• aged 30 or over
• resident on Reunion island and followed at the University Hospital of Reunion Island (the only follow-up center on the island)
• Able to perform anal self-sampling
• Able to answer a questionnaire
• Affiliated with or benefiting from a social security scheme
• Have given free, informed and signed consent

You may not qualify if…

• People with a previous anal swab less than 7 days old
• Persons with a known current diagnosis of anal cancer
• Persons deprived of liberty by judicial or administrative decision, minors, and persons under legal protection: guardianship or curators

Where it is running

• CHU de la Réunion Recherche Clinique — Saint-Pierre, Reunion (enrolling)
• CHU de la Réunion Recherche Clinique — Saint-Denis, Reunion

Full record on ClinicalTrials.gov

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