Night Owl Metabolism
Recruiting now · Not applicable
Conditions studied: PreDiabetes, Overweight, Impaired Glucose Tolerance
In brief
The proposed study uses a novel and rigorous randomized cross-over study design in youth (18-23y) with late and non-late chronotype (n=35 per group) to assess the glycemic effect of "aligning" an oral glucose tolerance test (OGTT) or first-meal of day to a subject's chronotype. Both groups will undergo 2 OGTTs (aligned and mis-aligned with chronotype) to compare glucose tolerance and insulin sensitivity within-subject (primary outcome) and between groups (Aim 1). Then, youth will also undergo two standardized meals (aligned and mis-aligned with chronotype) while wearing continuous glucose monitoring to compare post-prandial glucose excursions within-subject and between groups (Aim 2). A pilot Exploratory Aim 3 (n=12 per group) will investigate delayed melatonin patterns under dim-light as a potential pathophysiologic mechanism behind abnormal glucose tolerance in youth with late chronotype on morning OGTTs.
Key facts
- Study ID
- NCT06507722
- Run by
- Johns Hopkins University
- People needed
- 70
- Starts
- 2025-02-25
- Expected to finish
- 2030-01-31
- Last updated by the study team
- 2026-05-11
Who can join
Age: 18 and older, up to 23. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Overweight similar to (BMI ≥ 85th percentile but <95th percentile for age and sex per Centers for Disease Control and Prevention growth curves (as Centers for Disease Control and Prevention growth curves contain ages ≤ 20y; if ages 21-23 years, the BMI ≥ 85th and <95th percentile equivalents for a 20-year-old will be used))
- Post-pubertal
- Normal sleep duration (avg. >7 hours of sleep per night)
- Social jetlag (difference between weekend and weekday sleep) of < 2 hours.
You may not qualify if…
- Known diabetes, sleep disorders, major organ system illness, pregnancy, or genetic syndrome
- Medication use known to affect insulin sensitivity, glucose tolerance, or circadian rhythm
- Screening high risk for obstructive sleep apnea
- Night shift work.
Where it is running
- Johns Hopkins School of Medicine — Baltimore, Maryland, United States (enrolling)
Full record on ClinicalTrials.gov
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