Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults (M3AX)
Recruiting now · Not applicable
Conditions studied: Aging, Aging Well
In brief
Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately manifest in physical, mental, and metabolic impairments that compromise healthspan and quality of life. Exercise is a multipotent treatment with promise to mitigate most aging hallmarks, but there is substantial variability in exercisƒe responsiveness. Combining endurance and resistance training in alignment with public health guidelines will be used to better understand variable exercise responsiveness in older adults with the ultimate goal of improving each older adult's capacity to attain the many health benefits of exercise.
Key facts
- Study ID
- NCT06507189
- Run by
- Florida Institute for Human and Machine Cognition
- People needed
- 250
- Starts
- 2025-01-27
- Expected to finish
- 2029-08-31
- Last updated by the study team
- 2026-08-10
Who can join
Age: 60 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Male or female aged 60 or above
- Free of chronic disease
- No structured exercise program (2 or more bouts/wk) within previous 12 months
- Cognitively capable of providing informed consent
You may not qualify if…
- Neuromuscular or musculoskeletal disorder that would limit ability to perform the exercise and/or testing bouts
- Cardiopulmonary disorders or reduced breathing capacity
- Metabolic diseases including markers of liver disease (ALT > 52 U/l) and type 2 diabetes (HbA1C = or > 6.5, fasting blood glucose = or > 126 mg/dl)
- Any other disease or disorder that would influence exercise response (e.g., chronic kidney disease, dementia, current cancer diagnosis or within 2 yr remission, cerebrovascular disease)
- Any current infectious disease
- Life expectancy < 1 year
- Insulin sensitizing/blood glucose lowering agents such as metformin or metabolic weight loss agents (e.g. GLP-1 agonists)
- High dose statin (dose equivalent of 40 mg/d or higher simvastatin)
- Lidocaine allergy
- Regular tobacco use and/or vaping
- Excessive alcohol consumption (3 drinks/d or 7 drinks/wk for females; 4 drinks/d or 14 drinks/wk for males)
- BMI 35.0 kg/m2 or higher
- Unable to commit to \~6 months required to complete the study
Where it is running
- Florida Institute for Human and Machine Cognition — Pensacola, Florida, United States (enrolling)
- Oklahoma Medical Research Foundation — Oklahoma City, Oklahoma, United States (enrolling)
Full record on ClinicalTrials.gov
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