Genetic and Epigenetic Background of Inner Ear Dysfunction in Turner Syndrome

Recruiting now

Conditions studied: Sensorineural Hearing Loss, Turner Syndrome, Inner Ear Disease

In brief

The goal of this case-control study is to pave the way for new revolutionary treatment measures within hearing loss that could either replace or delay the need for hearing aids. The study focuses on people with Turner syndrome (TS). The aim is to find out if there are specific DNA methylation patterns and/or RNA expression profiles linked to sensorineural hearing loss (SNHL) in people with TS. Additionally, the structure and function of the inner ear in these individuals will be examined to see if there is a connection to their epigenetic profile. The main question it aims to answer is: Does epigenetics constitute a common denominator for some of the unexplained SNHL cases? Turner Syndrome (TS) represents an ideal model for studying epigenetics related to sensorineural hearing loss (SNHL). Participants will undergo the following tests: * Ear examinations * Hearing tests * Balance tests * Blood tests * MRI scans * CBCT (cone-beam computed tomography) scans

Key facts

Study ID

NCT06507007

Run by

Gødstrup Hospital

People needed

150

Starts

2025-02-01

Expected to finish

2027-07-30

Last updated by the study team

2026-01-27

Who can join

Age: 18 and older, up to 60. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• age between 18 and 60 years old

You may not qualify if…

• Contraindications for the MRI or CBCT
• Serious medical disorders
• Neurological or psychiatric disorders of any kind
• Use of medication that is known to influence inner ear function
• Medical history with dizziness or hearing problems (controls only)

Where it is running

• ENT department of Gødstrup Hospital — Herning, Denmark (enrolling)

Full record on ClinicalTrials.gov

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