Nausea Induced by Radiation of the Dorsal Vagal Complex for Benign Brain Tumors (NausiCAA)

Recruiting now

Conditions studied: Benign Brain Tumor

In brief

Patients irradiated to the brain frequently experience nausea. The dorsal vagal complex (DVC) area is a specific brainstem zone and has been identified as likely responsible for nausea. Existing clinical studies show correlation between dose to the DVC and nausea, but they concern tumors of the airways and upper digestive tract, where there are many confounding factors. The aim of this study is to establish a ling between radiation dose to the DVC and nausea. Defining a dose threshold to the DVC will allow radiation oncologists to optimize radiation dose distribution and reduce nausea in patients.

Key facts

Study ID

NCT06506578

Run by

University Hospital, Bordeaux

People needed

100

Starts

2022-05-20

Expected to finish

2026-06-01

Last updated by the study team

2025-07-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• More than 18 years old
• With benign brain tumor
• Irradiated with conventional fractionation (1,8-2Gy/fraction)

You may not qualify if…

• History of brain radiation
• History of head and neck radiation
• Demencia
• Concurrent chemotherapy
• Nausea at the time of inclusion
• Anti-nausea treatment : corticosteroids, metoclopramide, setrons, other

Where it is running

• CHU de Bordeaux, Service de Radiothérapie — Bordeaux, France (enrolling)
• Hospices Civils de Lyon, Service d'Oncologie Radiothérapie - Hôpital Neurologique — Lyon, France
• Institut de cancérologie Strasbourg Europe (ICANS), Service d'Oncologie Radiothérapie — Strasbourg, France

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.