Ketamine for Methamphetamine Use Disorder
Running, not enrolling · Phase 2
Conditions studied: Substance Use Disorders, Substance Use, Methamphetamine Abuse
In brief
This study aims to determine whether treatment response with IV ketamine is superior to treatment response with IV midazolam in adults with moderate to severe MUD. The study design is a 12-week randomized, double-blind, controlled trial comparing intravenous (IV) ketamine against IV midazolam, delivered over six weeks in 120 adults with moderate to severe methamphetamine use disorder (MUD).
Key facts
- Study ID
- NCT06496750
- Run by
- University of Texas Southwestern Medical Center
- People needed
- 120
- Starts
- 2024-09-11
- Expected to finish
- 2026-10-01
- Last updated by the study team
- 2026-08-04
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Study participants must:
- Be 18 to 65 years old
- Be able to sufficiently understand, speak, and read English
- Be interested in reducing or stopping methamphetamine use
- Meet criteria for methamphetamine use disorder
- Use acceptable methods of contraception during participation in the study
You may not qualify if…
- Study participants must not:
- Have been in a research study of pharmacological or behavioral treatment for addiction within 6 months prior to written informed consent
- Be currently in jail, prison, or inpatient overnight facility as required by court of law
- Have upcoming surgery planned or scheduled
- Be currently pregnant, breastfeeding, or planning on conception, if biologically female
- Additional inclusion and exclusion criteria will be assessed by the study investigators at the screening visit.
Where it is running
- Alameda Health System — San Leandro, California, United States
- Interdisciplinary Substance Use and Brain Injury Facility — Albuquerque, New Mexico, United States
- Addiction Institute of Mount Sinai — New York, New York, United States
- Prisma Health — Greenville, South Carolina, United States
- UT Southwestern Medical Center — Dallas, Texas, United States
Full record on ClinicalTrials.gov
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