Antidepressant Adherence for Depressed Adults in Primary Care

Recruiting now · Not applicable

Conditions studied: Depression

In brief

The goal of this study is to test ways to help people improve their health and manage their medication for depression. This study will measure both medication adherence and depression outcomes.

Key facts

Study ID

NCT06496646

Run by

University of Pennsylvania

People needed

525

Starts

2025-03-19

Expected to finish

2029-03-31

Last updated by the study team

2025-11-26

Who can join

Age: 21 and older, up to 64. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Penn Medicine primary care outpatients
• Clinical diagnosis of major depressive disorder
• A score of 10+ on the Patient Health Questionnaire 9 (PHQ-9)
• Age 21 to 64 years at the time of study entry
• Prescribed an antidepressant by their primary care clinician
• Express interest in taking antidepressant medication
• Own a cell phone
• Capable of using the electronic pill bottle
• English-speaking

You may not qualify if…

• Treated with antidepressants in the past 90 days
• Pregnant or breastfeeding
• An active substance use disorder other than nicotine
• A lifetime history of treatment for bipolar disorder or schizophrenia
• Hospital admission or emergency department visit for suicidal symptoms in the past year
• Lack capacity to provide informed consent
• Using antidepressant more than 10 days at baseline assessment

Where it is running

• University of Pennsylvania Health System — Philadelphia, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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