Danish Vulva Cancer Recurrence Study
Recruiting now · Not applicable
Conditions studied: Vulva Cancer, Vulva Neoplasm, Vulvar Cancer, Vulva Disease, Vulvar Neoplasms, Vulvar Diseases, PROM, Circulating Tumor DNA, Survivorship
In brief
The overall aim is to investigate different aspects of recurrence detection in women with vulva cancer (VC) to identify optimal treatment- and surveillance programs. DaVulvaRec is a Danish nationwide multicenter study with patient inclusion from Aarhus University Hospital and Rigshospitalet, Denmark. Applying a mixed method research design, the investigators will collect and analyze patient-reported outcome measures in combination with procedural data to evaluate symptomatology and map actions taken during the patient's pathway from primary disease to recurrence. Furthermore, the investigators aim to examine if circulating tumor-DNA (ctDNA) can be detected in liquid biopsies from VC patients. All patients will be followed for two years or until recurrence. Patient-reported outcome measures will be completed every four months during surveillance, and liquid biopsies will be collected prospectively for later analyses. Total number of patients to be included is 295 according to a power calculation. All patients in the clinical study will be included in the intervention group, while data on a historical control group will be obtained from The Danish Gynecological Cancer Database. Hence, the control group will consist of 1000 VC patients diagnosed between 2011-2022. Hypotheses: * All patients with VC will have specific tumor markers in the primary tumor that will be detectable in liquid biopsies as ctDNA at the time of diagnosis. * Measurement of ctDNA after primary treatment and during surveillance will allow detection of residual disease, improve allocation for adjuvant treatment, and will allow early detection of recurrent VC. * Proactive use of repeated PROM assessments in combination with procedural actions during surveillance will allow early detection of recurrent VC and early identification of late effects after treatment.
Key facts
- Study ID
- NCT06495554
- Run by
- University of Aarhus
- People needed
- 1295
- Starts
- 2024-08-15
- Expected to finish
- 2030-12-31
- Last updated by the study team
- 2026-04-29
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Primary or recurrent biopsy-verified squamous cell carcinoma of the vulva
- ≥ 18 years of age
- Able to understand oral and written information in Danish
You may not qualify if…
- Active treatment for concurrent cancer and/or dissemination of concurrent cancer
Where it is running
- Aarhus University Hospital — Aarhus N, Denmark (enrolling)
- Copenhagen University Hospital — Copenhagen, Denmark (enrolling)
Full record on ClinicalTrials.gov
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