The Efficacy and Safety of Pulsed Radiofrequency Combined With Platelet-rich Plasma for Infraorbital Neuralgia

Recruiting now

Conditions studied: Infraorbital Neuralgia, Platelet-rich Plasma

In brief

This is a multicenter, prospective, observational, propensity score matching, cohort, and assessor-blinded study designed to compare the effectiveness and safety of PRP injections combined with PRF treatment with PRF alone in patients with IONa who are responded poorly to conventional therapies and are reluctant to receive destructive therapies for seeking a better minimally invasive treatment strategy.

Key facts

Study ID

NCT06492213

Run by

Beijing Tiantan Hospital

People needed

240

Starts

2024-07-01

Expected to finish

2027-07-01

Last updated by the study team

2025-02-21

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age between 18 to 75 years;
• Paroxysmal or persistent stabbing pain in the distribution area of the infraorbital nerve and positive response to diagnostic block (1 ml of 2% lidocaine) prior to treatment;
• NRS score≥7;
• Scheduled for PRF treatment for IONa；
• Signed informed consent.

You may not qualify if…

• Platelet count <105*109/L, ongoing anticoagulation therapy or antiplatelets treatment, coagulation disorders or bleeding disorders;
• Severe cardiopulmonary or hepatorenal dysfunction;
• Infection at the puncture site; .
• Neuralgia secondary to tissue damage around the infraorbital foramen from causes such as maxillary sinusitis or tumor;
• History of destructive treatments such as radiofrequency thermocoagulation, chemical ablation, infraorbital neurectomy, infraorbital nerve avulsion, etc;
• History of mental disorders；
• History of narcotic drug abuse;
• Unable to cooperation.

Where it is running

• Fang Luo — Beijing, Beijing Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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