The Peripheral Blood Multi-Omics Study on Sleep Loss
Recruiting now · Not applicable
Conditions studied: Sleep Deprivation, Aging, Alzheimer Disease, Healthy Lifestyle, Cognitive Decline, Shift-work Disorder
In brief
Sleep plays a role in cognitive processes such as memory processing, attention processing, and overall cognitive function. In recent years, the bidirectional relationship between sleep loss and aging, as well as related neurodegenerative diseases, has garnered widespread attention. Sleep disorders are a typical clinical manifestation of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease and are closely related to the progression of these diseases. However, current research has yet to fully elucidate the physiological responses to sleep loss across different ages and cognitive levels, as well as the association and molecular basis between sleep loss, aging, and neurodegenerative diseases. This study aims to comprehensively characterize the transcriptional and metabolic changes in peripheral blood under sleep loss in populations of different ages and cognitive levels using multi-omics approaches and to preliminarily explore the role of sleep loss in aging and AD.
Key facts
- Study ID
- NCT06492109
- Run by
- First Affiliated Hospital of Zhejiang University
- People needed
- 60
- Starts
- 2024-06-20
- Expected to finish
- 2025-12-31
- Last updated by the study team
- 2025-07-31
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Signed informed consent form；
- Meet the inclusion criteria for each arms.
You may not qualify if…
- Failure to provide informed consent;
- Inability to follow study procedures due to issues such as language barriers or cognitive impairment;
- Regular use of medications that may alter the relationship between sleep and outcome variables (e.g., opioid medications, benzodiazepines, and Z drugs [non-benzodiazepine hypnotics]);
- History of alcohol abuse, substance abuse, consciousness disorders, cerebrovascular disease, head injury, epilepsy, encephalitis, or other neurological disorders;
- Diagnosis of schizophrenia, severe depression, anxiety disorders, or other severe psychiatric conditions;
- Presence of severe arrhythmias, myocardial infarction within the last 6 months, severe pulmonary dysfunction, renal or hepatic insufficiency, severe anemia, severe gastrointestinal diseases, tumors, or other severe medical conditions.
Where it is running
- The First Affiliated Hospital of Zhejiang University — Hangzhou, Zhejiang, China (enrolling)
Full record on ClinicalTrials.gov
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