Speech Motor Learning and Retention (Aim 2)
Recruiting now · Not applicable
Conditions studied: Speech
In brief
The overall goal of this research is to test a new model of speech motor learning, whose central hypothesis is that learning and retention are associated with plasticity not only in motor areas of the brain but in auditory and somatosensory regions as well. The strategy for the proposed research is to identify individual brain areas that contribute causally to retention by disrupting their activity with transcranial magnetic stimulation (TMS). Investigators will also use functional magnetic resonance imaging (fMRI) which will enable identification of circuit-level activity which predicts either learning or retention of new movements, and hence test the specific contributions of candidate sensory and motor zones. In other studies, investigators will record sensory and motor evoked potentials over the course of learning to determine the temporal order in which individual sensory and cortical motor regions contribute. The goal here is to identify brain areas in which learning-related plasticity occurs first and which among these areas predict subsequent learning.
Key facts
- Study ID
- NCT06491823
- Run by
- Yale University
- People needed
- 120
- Starts
- 2024-10-01
- Expected to finish
- 2029-05-31
- Last updated by the study team
- 2026-02-19
Who can join
Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Fluent English speakers
- Right-handed
- Normal hearing
- No speech disorder or reading disability
You may not qualify if…
- Cardiac pacemaker
- Aneurysm clip
- Heart or Vascular clip
- Prosthetic valve
- Metal implants
- Metal in brain, skull, or spinal cord
- Implanted neurostimulator
- Medication infusion device
- Cochlear implant or tinnitus (ringing in ears)
- Personal and/or family history of epilepsy or other neurological disorders or history of head concussion
- Psychoactive medications
- Pregnancy
Where it is running
- Yale Child Study Center — New Haven, Connecticut, United States (enrolling)
Full record on ClinicalTrials.gov
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