Effects of Dexmedetomidine Versus Ketamine on Inflammatory Response and Hemodynamic in Patients

Recruiting now · Phase 1/Phase 2

Conditions studied: Haemodynamic Rebound

In brief

Inflammatory response and hemodynamic response in patients with intraabdominal sepsis and Effects of Dexmedetomidine versus ketamine on it .

Key facts

Study ID

NCT06490731

Run by

New Valley University

People needed

2

Starts

2026-04-01

Expected to finish

2026-10-01

Last updated by the study team

2026-05-07

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• • Adult patients admitted to ICU after ileus surgery (perforated viscus, infarcted bowel, strangulated hernia, anastomotic leakage, diverticulitis, and intestinal obstruction), and who will be expected to require postoperative sedation and ventilation.
• Abdominal sepsis was determined as organ dysfunction with a substantial change in overall SOFA score (2) ≥ 2 points because of intra-abdominal sepsis.

You may not qualify if…

• • Known allergy to ketamine, dexmedetomidine,
• Confirmed pregnancy,
• Heart failure (class 3 or 4 of the New York Heart Association),
• Renal failure (RIFLE classification),
• Liver failure (manifested by serum total protein concentration <3 g/dl and total bilirubin >5 mg/dl)
• Known or suspected brain death.
• Patients who receive neuromuscular blockers during the first 48 hours of ICU admission will also be excluded.

Where it is running

• asyut University — Asyut, Egypt (enrolling)

Full record on ClinicalTrials.gov

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