Unraveling the Impact of Thalidomide at Diverse Doses in Transfusion Dependent Beta Thalassemia
Recruiting now · Phase 2
Conditions studied: Fetal Hemoglobin, Thalassemia Major, Genetic Disease
In brief
The project "Unraveling the Impact of Thalidomide at Diverse Doses in Transfusion Dependent Beta Thalassemia" investigates the safety and efficacy of low-dose thalidomide in managing beta thalassemia, a genetic disorder causing anemia. Conducted over two years at NIBD hospital, the study involves 54 transfusion-dependent patients aged 8-35. The primary objective is to correlate thalidomide doses with disease severity, adverse effects, and treatment response, aiming to optimize treatment strategies and reduce side effects. Data will be collected through clinical interviews and medical record reviews and analyzed using SPSS. Key variables include hemoglobin levels, leukocyte and reticulocyte counts, platelets, liver and spleen size, genetic modifiers, and transfusion frequency. Inclusion criteria are specific to beta thalassemia patients, while exclusion criteria rule out those with liver dysfunction, married patients, lactating mothers, and those with a history of thrombosis or fits.
Key facts
- Study ID
- NCT06490627
- Run by
- National Institute of Blood and Marrow Transplant (NIBMT), Pakistan
- People needed
- 54
- Starts
- 2024-04-22
- Expected to finish
- 2026-04-22
- Last updated by the study team
- 2025-05-30
Who can join
Age: 8 and older, up to 35. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Know case of beta thalassemia major/ intermediate ( transfusion dependent)
- willing to give informed consent
You may not qualify if…
- Patients with comorbidities such as liver dysfunction
- Married patients
- Lactating mother
- H/O thrombosis and fits
Where it is running
- National Institute of blood disease and bone marrow transplant — Karachi, Sindh, Pakistan (enrolling)
Full record on ClinicalTrials.gov
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