Predicting the Efficacy in Advanced Gastric Cancer.

Completed

Conditions studied: Gastric Cancer, Chemotherapy Effect, Paclitaxel, Ramucirumab

In brief

With advances in chemotherapy for gastric cancer, it is important to identify patients who will respond effectively to specific therapies. This longitudinal study aimed to establish a liquid-biopsy assay that can predict response to ramucirumab plus paclitaxel therapy in patients with advanced gastric cancer.

Key facts

Study ID

NCT06490055

Run by

City of Hope Medical Center

People needed

162

Starts

2018-10-01

Expected to finish

2025-07-01

Last updated by the study team

2025-07-18

Who can join

Age: 20 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• unresectable or recurrent GC histologically confirmed to be primary adenocarcinoma of the stomach.
• age over 20 years.
• Eastern Cooperative Oncology Group performance status score of 0-2.
• written informed consent following full study information is provided to the patient.
• progression or intolerance for first-line chemotherapy comprising fluorinated pyrimidine and platinum anticancer drugs (cisplatin or oxaliplatin) for advanced GC.
• presence of evaluable lesions as confirmed using a computed tomography (CT) or magnetic resonance imaging.

You may not qualify if…

• Patients with a life expectancy of shorter than 3 months
• Patients with severe complications (angina pectoris, myocardial infarction, or arrhythmia) or uncontrollable diabetes mellitus, blood hypertension, or bleeding tendency.
• Patients with a history of serious allergic reactions or serious drug allergy.
• Patients with a clinically relevant mental disorder that prohibits response to questionnaires.
• Patients for whom the attending physician considered that enrollment in the study is inappropriate.

Where it is running

• Department of Molecular Diagnostics and Experimental Therapeutics — Monrovia, California, United States
• Kawasaki Medical University — Kurashiki, Okayama-ken, Japan

Full record on ClinicalTrials.gov

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