The Effect of a Methylprednisolone Taper on Outcomes Following Total Knee Arthroplasty

Withdrawn before enrolling · Phase 4

Conditions studied: Arthritis Knee, Knee Osteoarthritis, Pain, Postoperative

In brief

Pain control and early range of motion following total knee arthroplasty are essential for patient satisfaction. Intraoperative steroids (dexamethasone) have been shown to have a significant effect in controlling acute pain following total knee arthroplasty. This study aims to evaluate the effect of a post-operative steroid (methylprednisolone) taper in improving functional and patient-reported outcomes following total knee arthroplasty. A taper means taking a high dose of a medication followed by taking lower doses and each following day until the medication is stopped.

Key facts

Study ID

NCT06489626

Run by

F. Johannes Plate

People needed

0

Starts

2025-11-01

Expected to finish

2027-12-01

Last updated by the study team

2026-02-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients indicated for primary total knee arthroplasty.
• Access to computer or smartphone for completion of REDCap surveys

You may not qualify if…

• Patients less than 18 years of age, patients unable to consent, known diabetic patients and those with an HgbA1c >6.5 preoperatively, patients who are on chronic steroid treatments, patients with chronic pain on opioid management, patients with allergies to steroids, patients with a history of peptic ulcer disease, patients with a history of heart failure and patients with a history of renal and/or hepatic failure will be excluded. Those that are immunosuppressed as well as pregnant and/or lactating will also be excluded.

Where it is running

• UPMC East — Monroeville, Pennsylvania, United States
• UPMC Shadyside Hospital — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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