Mechanisms for Laser-Induced Rejuvenation

Recruiting now · Not applicable

Conditions studied: Skin Cancer

In brief

It has shown that laser wounding of geriatric skin protects it against skin cancer. The purpose of this study is to determine the origin of cells called fibroblasts which are present after treatment with Fractionated Laser Resurfacing (FLR). These cells restore a youth-like ultraviolet B (UVB) response, but where they come from is currently unknown. The study recruits subjects who are scheduled to undergo abdominoplasties to investigate the origin of those cells stimulated by laser treatment.

Key facts

Study ID

NCT06489301

Run by

Wright State University

People needed

12

Starts

2025-07-16

Expected to finish

2028-12-01

Last updated by the study team

2026-05-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult males and females 18 and older
• Able to comprehend procedures and risks
• Planning to undergo abdominoplasty surgery
• Minimum amount of skin to be removed is 50 x 20cm

You may not qualify if…

• Medical history of not well-controlled diabetes. This is defined as a subject who needs high doses of insulin, recent history of hospitalization for diabetes-related complications, or poor wound health as evidenced by diabetic ulcers. Subjects who have been deemed healthy enough for abdominoplasty surgery would tend to suggest that their diabetes should not be an issue. However, if the subjects have diabetic complications as outlined above, they could affect the wound healing which is the object of this protocol so they would be excluded.
• Pregnant or nursing
• History of pathologically abnormal wound healing such as keloidal scars
• Existing tattoos on the abdomen that are so extensive that they could interfere with the study

Where it is running

• Pharmacology Translational Unit — Fairborn, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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