Preoperative Use of Pantoprazole for Prevention of Post Operative Nausea and Vomiting in Gynecologic Surgery
Recruiting now · Phase 2 · Has a placebo group
Conditions studied: Postoperative Nausea and Vomiting
In brief
The goal of this clinical trial is to see if pantoprazole (a proton pump inhibitor used for acid reflux/heart burn) can reduce nausea and vomiting after gynecologic surgery in women between the ages of 18 and 79. Researchers will compare a placebo to the active medication. Participants will be asked to take three pills around their surgery, two taken before and one taken the night after.
Key facts
- Study ID
- NCT06488001
- Run by
- United States Naval Medical Center, Portsmouth
- People needed
- 132
- Starts
- 2022-08-26
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2025-05-21
Who can join
Age: 18 and older, up to 79. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Undergoing elective gynecological surgery by either an open abdominal or minimally invasive approach (to include both endoscopic and vaginal). Procedure must be performed under general anesthesia.
You may not qualify if…
- Pregnant,
- Patients with gastrointestinal disease requiring ongoing medical management.
- Prior gastrointestinal surgery with the exception of diagnostic procedures, appendectomy and cholecystectomy.
- Patients with a history of H2 receptor blocker use, proton pump inhibitor use or other GERD specific therapy within 30 days of surgery.
- Any patient identified by their surgical care team as having a history of PONV warranting additional perioperative prophylaxis.
- Known r suspected malignancy
- Lactose intolerance
Where it is running
- Naval Medical Center Portsmouth — Portsmouth, Virginia, United States (enrolling)
Full record on ClinicalTrials.gov
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