Shunt-dependency After aSAH - Role of Early Hyperglycaemia in CSF and Blood

Recruiting now

Conditions studied: Aneurysm, Ruptured, Hyperglycemia, Hydrocephalus

In brief

The goal of this study is to confirm the association of early increased glucose levels in cerebro-spinal fluid (CSF) and ventriculo-peritoneal-shunt (VPS)-dependency also evaluating the influence of blood glucose on VPS dependency in patients suffering from an aneurysmal subarachnoid haemorrhage (aSAH). The main questions we aim to answer are: * Is there an association of glucose levels on VPS dependency in patients requiring extra-ventricular-drain (EVD) placement for aSAH? * In addition, if there is, what is the influence the course of glucose levels has on VPS dependency? Glucose levels in CSF and serum will be measured on admission, or in case of CSF, upon EVD placement. Glucose in CSF will then be measured every day until EVD removal together with serum glucose. Follow-up will be conducted in person after 3 and 6 months.

Key facts

Study ID

NCT06486909

Run by

Isabel Hostettler

People needed

160

Starts

2024-03-26

Expected to finish

2028-09-01

Last updated by the study team

2026-03-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years old and older
• Hospital admission due to an aneurysmal subarachnoid haemorrhage (radiological confirmation needed)

You may not qualify if…

• Younger than 18 years old
• Non-aneurysmal subarachnoid haemorrhage (eg. trauma, perimesencephalic subarachnoid haemorrhage, mycotic or flow-associated aneurysms)
• Previous enrolment into the current study

Where it is running

• Cantonal Hospital Aarau — Aarau, Switzerland (enrolling)
• University Hospital Basel — Basel, Switzerland (enrolling)
• Cantonal Hospital St Gallen — Sankt Gallen, Switzerland (enrolling)

Full record on ClinicalTrials.gov

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