Pericardiotomy in Cardiac Surgery

Recruiting now · Not applicable

Conditions studied: Atrial Fibrillation, Atrial Flutter, Cardiac Events

In brief

PRINCE is an international, multicentre, randomized controlled trial of posterior pericardiotomy in patients without a history of atrial fibrillation (AF) or flutter undergoing cardiac surgery.

Key facts

Study ID

NCT06486636

Run by

Population Health Research Institute

People needed

1400

Starts

2024-10-21

Expected to finish

2031-09-01

Last updated by the study team

2025-07-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients greater than or equal to 18 years of age
• Requiring surgical intervention on the proximal aorta, cardiac valves, and/or coronary arteries
• Able to provide informed consent

You may not qualify if…

• History of atrial fibrillation or flutter
• Cardiac surgery procedures not included in the inclusion criteria (planned ventricular assistance device, aortic arch, transplantation surgery)
• Prior cardiac surgery requiring opening of the pericardium
• Previous surgical instrumentation of the left pleural cavity
• Patient undergoing minimally invasive cardiac surgery

Where it is running

• Weill Cornell Medicine — New York, New York, United States (enrolling)
• Medical University Vienna — Vienna, State of Vienna, Austria (enrolling)
• Hamilton Health Sciences — Hamilton, Ontario, Canada (enrolling)
• University of Foggia, Policlinico Foggia — Foggia, Foggia, Italy (enrolling)

Full record on ClinicalTrials.gov

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