Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Participants With Endometrial Cancer After Platinum-Based Chemotherapy and Immunotherapy (ASCENT-GYN-01/GOG-3104/ENGOT-en26)
Running, not enrolling · Phase 3
Conditions studied: Endometrial Cancer
In brief
The goal of this clinical study is to find out how the study drug, sacituzumab govitecan (SG) works in participants with endometrial cancer who have received prior treatment with platinum-based chemotherapy and immunotherapy, versus the treatment of physician's choice (TPC). The primary objectives of this study are to evaluate the effect of SG compared to TPC on progression-free survival (PFS) as assessed by blinded independent central review (BICR) and overall survival (OS).
Key facts
- Study ID
- NCT06486441
- Run by
- Gilead Sciences
- People needed
- 640
- Starts
- 2024-08-28
- Expected to finish
- 2029-06-01
- Last updated by the study team
- 2026-07-29
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
Where it is running
- City of Hope — Duarte, California, United States
- UC San Diego Medical Center — La Jolla, California, United States
- Cedars-Sinai Cancer at Cedars-Sinai Medical Center — Los Angeles, California, United States
- Stanford Women's Cancer Center — Palo Alto, California, United States
- Kaiser Permanente Medical Center — Vallejo, California, United States
- University of Colorado Hospital - Anschutz Cancer Pavilion (ACP) — Aurora, Colorado, United States
- Hartford HealthCare Cancer Institute at Hartford Hospital — Hartford, Connecticut, United States
- Yale University School of Medicine — New Haven, Connecticut, United States
- Florida Cancer Specialists — Fort Myers, Florida, United States
- University of Florida — Gainesville, Florida, United States
- Baptist MD Anderson Cancer Center — Jacksonville, Florida, United States
- Winship Cancer Institute, Emory University — Atlanta, Georgia, United States
- Lewis Cancer & Research Pavilion at St. Joseph's/Candler Health System — Savannah, Georgia, United States
- Northwestern Memorial Hospital — Chicago, Illinois, United States
- University of Chicago Medical Center — Chicago, Illinois, United States
- Indiana University Melvin and Bren Simon Comprehensive Cancer Center — Indianapolis, Indiana, United States
- Baptist Health Lexington — Lexington, Kentucky, United States
- Norton Cancer Institute — Louisville, Kentucky, United States
- Ochsner Clinic Foundation — New Orleans, Louisiana, United States
- Greater Baltimore Medical Center — Baltimore, Maryland, United States
- Tufts Medical Center — Boston, Massachusetts, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Baystate Medical Center — Springfield, Massachusetts, United States
- West Michigan Cancer Center — Kalamazoo, Michigan, United States
- University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
Full record on ClinicalTrials.gov
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