Intravenous Oxytocin for Post Operative Pain After Minimally Invasive Hysterectomy
Recruiting now · Phase 2 · Has a placebo group
Conditions studied: Postoperative Pain
In brief
This is a randomized, double-blinded, placebo-controlled trial to compare the effectiveness of IV oxytocin infusion to placebo on peri-operative opioid consumption and reducing post-operative pain following a minimally invasive hysterectomy under general anesthesia.
Key facts
- Study ID
- NCT06483659
- Run by
- Brigham and Women's Hospital
- People needed
- 152
- Starts
- 2025-06-01
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2025-12-30
Who can join
Age: 18 and older, up to 65. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Ages 18-65 years old
- ASA category 1-3
- Scheduled to undergo minimally invasive hysterectomy
- No documented allergy to oxytocin
You may not qualify if…
- American Society of Anesthesiologists (ASA) group 4 or greater
- Age >65 years old
- Additional surgical procedures including but not limited to minor laparotomy, omentectomy, cystectomy, vaginectomy, and/or ablation of endometriosis.
- Active opioid prescription of the equivalent of oxycodone >10 mg /day
- Opioid use disorder, including patients in treatment receiving naltrexone or Suboxone (Buprenorphine-naloxone)
- Allergies to any study medication: acetaminophen, celecoxib, ketorolac, fentanyl, hydromorphone, or oxycodone.
- Epidural/Regional anesthesia for intra-operative or post-operative pain.
- Inability to understand the questionnaires
- Intra-operative and post-operative exclusion: Procedure converted to open or extension of primary surgery, Intra-operative EBL >500 ml., Placement of epidural catheter or regional anesthesia at PACU for pain management, Hospitalization of the patient due to surgical or anesthetic complications
Where it is running
- Brigham and Women's Hospital — Boston, Massachusetts, United States (enrolling)
Full record on ClinicalTrials.gov
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