Promoting Improved Functioning Among People Experiencing Stressful Situations
Recruiting now · Not applicable
Conditions studied: Acute Stress Reaction
In brief
The iCOVER intervention was developed to rapidly restore functioning in individuals experiencing an Acute Stress Reaction (ASR). iCOVER is undergoing widespread adoption but has not been tested for efficacy. iCOVER was designed to be administered by peers, paraprofessionals, or medical personnel in 60-120 seconds, including in military operational environments. The term iCOVER is an acronym that summarizes the six specific steps of the intervention: (1) identify that an individual is experiencing an ASR; (2) Connect with the individual through word, eye contact, and physical touch to draw them back to the present moment; (3) Offer commitment so that the individual feels less psychologically isolated and withdrawn (e.g., "I'm right here with you"); (4) Verify facts - ask simple fact-based questions to engage the individual in deliberate cognitive activity; (5) Establish order of events - briefly review what has happened, what is happening, and what will happen to orient the individual; and (6) Request action to re-engage the individual in purposeful behavior. Participants will be randomly assigned to one of three groups: iCOVER, usual care, or physical presence with reassurance. Investigators have elected to use two different control conditions, in order to examine the reliability of the iCOVER intervention in comparison with two typical responses to individuals experiencing an ASR (i.e., physical presence with reassurance, no specific treatment).
Key facts
- Study ID
- NCT06482567
- Run by
- University of North Carolina, Chapel Hill
- People needed
- 450
- Starts
- 2024-08-15
- Expected to finish
- 2027-03-01
- Last updated by the study team
- 2025-12-09
Who can join
Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- ≥ 18 years and ≤ 50 years of age (if age not known, appears to be)
- In the emergency department as a patient or loved one of a patient
- If a patient, anticipated to be discharged to home from the emergency department after evaluation
- Exhibiting visible signs of distress Richmond Agitation and Sedation Scale ((RASS) (+1 to +3)) or dissociation (awake and alert but reduced responsiveness)
- Likely able to speak English
You may not qualify if…
- Known pregnancy
- Prisoner or in custody
- Known history of psychosis or bipolar disorder
- Known or suspected drug intoxication
- Known history of substantial cognitive impairment
- Known or suspected altered mental status due to traumatic brain injury
- Known active psychosis, suicidal ideation, or homicidal ideation
- Unable to use both hands (e.g. due to sprain)
- Any other history or condition that would, in the site investigator's judgement, indicate that the individual would very likely be non-compliant with the study or unsuitable for the study (e.g. might interfere with the study, confound interpretation, or endanger participant)
Where it is running
- University of Massachusetts Chan Medical School — Worcester, Massachusetts, United States (enrolling)
- Henry Ford Health System — Detroit, Michigan, United States (enrolling)
- Washington University, St. Louis — St Louis, Missouri, United States (enrolling)
- Cooper University Health Care — Camden, New Jersey, United States (enrolling)
- McLean Hospital, Harvard Medical School — Belmont, Massachusetts, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.