Timing of Resumption of Direct Oral Anticoagulants Following Polypectomy

Recruiting now · Not applicable

Conditions studied: Postpolypectomy Bleeding

In brief

The goal of this prospective randomized non-inferiority trial is to compare two different resumption time of Direct Oral Anticoagulants (DOACs) after colonoscopic polypectomy. We hypothesize that early resumption of DOACs after colonoscopy and polypectomy is associated with comparable post-polypectomy bleeding rate to those with delayed resumption. This study aims to compare the post-polypectomy bleeding risk of two different timing of resuming DOACs (Day 0 vs Day 2):

Key facts

Study ID

NCT06482333

Run by

The University of Hong Kong

People needed

194

Starts

2024-10-03

Expected to finish

2027-12-31

Last updated by the study team

2026-05-01

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All adult patients who are taking DOACs and schedule for elective colonoscopy are potentially eligible. We only included patients who had complete colonoscopy and with polypectomy performed.

You may not qualify if…

• Previous resection of any colonic segments,
• Inflammatory bowel disease or polyposis syndrome
• Patient with large polyp required advanced procedure e.g. endoscopic submucosal dissection (ESD) to remove
• Patients who develop immediate post-polypectomy bleeding during the procedure and requiring haemostasis will also be excluded
• Patient without polypectomy
• Patient without complete colonoscopy done

Where it is running

• Queen Mary Hospital, the University of Hong Kong — Hong Kong, Hong Kong (enrolling)

Full record on ClinicalTrials.gov

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