Suicide Specific Rumination in Veterans

Completed · Not applicable

Conditions studied: Depression, Suicide, Mood Disorders

In brief

Few treatments target core features of suicidal thoughts and behaviors in Veterans. Real-time functional magnetic resonance imaging neurofeedback can provide information regarding brain activation associated with suicide-specific rumination, defined as a "repetitive mental fixation on one's suicidal thoughts and intentions." The goal of this feasibility study is for Veterans to learn strategies for modulating activity within brain regions that have been demonstrated to contribute to the maintenance of rumination, as they receive neurofeedback feedback signals from the brain.

Key facts

Study ID

NCT06481033

Run by

VA Office of Research and Development

People needed

16

Starts

2024-08-01

Expected to finish

2026-04-07

Last updated by the study team

2026-08-10

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• U.S. military Veteran
• negative pregnancy test on MRI scan days
• score greater than or equal to 10 on the Suicide Rumination Scale
• clinically stabilized on psychotropic medications
• engaged in mental health care treatment
• able to provide written, informed consent

You may not qualify if…

• no major medical or neurological disorders that could interfere with treatment
• moderate or severe traumatic brain injury
• current imminent suicide risk, as determined through psychiatric interview, responses to C-SSRS, and clinical judgment of the assessor
• any current psychotic disorder
• MRI contraindications
• any substance use disorder for substances other than cannabis or alcohol (mild alcohol or cannabis use disorder does not exclude participants but moderate or severe alcohol or cannabis substance use disorder is disqualifying)
• pregnant or trying to become pregnant

Where it is running

• James J. Peters VA Medical Center, Bronx, NY — The Bronx, New York, United States

Full record on ClinicalTrials.gov

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