Modeling Host-Pathogen Interaction Using Lymphoid Organoids
Recruiting now
Conditions studied: Staphylococcal Infections
In brief
Background: Staphylococcus aureus (S.aureus) are bacteria that can make people sick. Sometimes, an S. aureus infection can develop inside the spine; these infections can lead to paralysis and death. Researchers do not know how S. aureus interacts with a person s cells to cause infections in the spine. Objective: To learn how S. aureus interacts with cells in the body using tissues from tonsils discarded after standard surgery to remove them. Eligibility: People aged 2 years and older who are scheduled to have their tonsils removed. Design: Researchers will select participants for the study based on review of their existing medical records, including results of blood tests; any imaging scans, including x-rays; and reports about tissue specimens. Participants will answer questionnaires about their health and past infections. They can do this online or on paper. Participants will collect a nasal swab 1 week before their surgery. They will be given a tool that looks like a long cotton swab. They will twirl it around inside their nose. The swab will pick up cells and fluids that will be used for research. After their surgery, the participant s surgeon will save samples of tonsil tissue. The surgeon will send these tissue samples and the nasal swab to researchers at the NIH. These tissues and the swab will be used in studies to help researchers understand how S. aureus interacts with cells in the body. They hope these studies will help them find better ways to treat S. aureus infections.
Key facts
- Study ID
- NCT06479837
- Run by
- National Institute of Allergy and Infectious Diseases (NIAID)
- People needed
- 500
- Starts
- 2026-08-13
- Expected to finish
- 2044-12-01
- Last updated by the study team
- 2026-08-10
Who can join
Age: 2 and older, up to 120. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- An individual who meets any of the following criteria will be excluded from participation in this study:
- Active infection.
- Active tonsilitis.
- Pregnant.
- Diagnosed with an immunosuppressive condition or currently taking immunosuppressive medications.
- Current or past intravenous drug use.
- Any condition that, in the judgment of the investigator, may put the participant at undue risk or make them unsuitable for participation in the study
Where it is running
- National Institute of Allergy and Infectious Diseases (NIAID) — Bethesda, Maryland, United States (enrolling)
- National Institutes of Health Clinical Center — Bethesda, Maryland, United States (enrolling)
Full record on ClinicalTrials.gov
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