Anti-cancer DC Cell Vaccination to Treat Solid Tumors
Recruiting now · Phase 1
Conditions studied: Solid Tumor, Adult, DC
In brief
Placental or tumor-derived heat shock protein gp96 is collected, purified, and stored. The DC cells are isolated from the patient's blood and then cocultured with the gp96 to obtain the activated DC cell product. The manufactured DC cells are subcutaneously or intra-tumor injected into the patient. Clinical studies will be performed to test anti-cancer function of the DC vaccination for immunotherapy of cancer patients. In this phase I study, the safety, tolerance, and preliminary efficacy of the DC vaccine immunotherapy on advanced cancers will firstly be evaluated.
Key facts
- Study ID
- NCT06477614
- Run by
- Second Affiliated Hospital of Guangzhou Medical University
- People needed
- 60
- Starts
- 2024-06-05
- Expected to finish
- 2035-12-30
- Last updated by the study team
- 2024-06-27
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with advanced cancer; 2. Life expectancy >12 weeks; 3. Adequate heart, lung, liver, kidney, and blood function; 4. Available high quality vaccine for human use; 5. Informed consent explained to, understood by and signed by patient/guardian. Patient/guardian given copy of informed consent.
You may not qualify if…
- Had accepted gene therapy before;
- Severe virus infection such as HBV, HCV, HIV, et al;
- Known HIV positivity;
- Active infectious disease related to bacteria, virus,fungi,et al;
- Other severe diseases that the investigators consider not appropriate;
- Pregnant or lactating women;
- Systemic steroid treatment (greater than or equal to 0.5 mg prednisone equivalent/kg/day);
- Other conditions that the investigators consider not appropriate.
Where it is running
- The Second Affiliated Hospital of Guangzhou Medical University — Guanzhou, Guangdong, China (enrolling)
Full record on ClinicalTrials.gov
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