Inflammation and Postoperative Atrial Fibrillation in Cardiac Surgery

Recruiting now

Conditions studied: Atrial Fibrillation, Inflammation

In brief

Postoperative atrial fibrillation (POAF) is a common complication after cardiac surgery, marked by an irregular and rapid heart rate, and associated with increased morbidity, longer hospital stays, and higher costs. Its complex pathophysiology involves atrial remodeling, inflammation, and autonomic dysregulation. Surgical trauma and cardiopulmonary bypass trigger an inflammatory response, releasing cytokines. Epicardial fat around the heart secretes pro-inflammatory cytokines, and its increased thickness is linked to higher inflammation and atrial fibrillation. This study uses RNA sequencing (RNA-seq) to profile gene expression in epicardial fat, identifying key genes involved in inflammation and metabolism. By comparing patients with and without POAF, RNA-seq reveals differentially expressed genes associated with postoperative atrial fibrillation.

Key facts

Study ID

NCT06475547

Run by

Odense University Hospital

People needed

100

Starts

2022-01-01

Expected to finish

2027-01-01

Last updated by the study team

2025-08-15

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age > 18
• Informed consent

You may not qualify if…

• Incompetent individuals
• General poor health condition at the time of inclusion
• Reoperation

Where it is running

• Odense University Hospital, Cardiac Surgery Department — Odense, Denmark (enrolling)

Full record on ClinicalTrials.gov

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