Effect of Ketalar or Dexmedetomidine on Increased Sensitivity to Pain Following Treatment With Remifentanil

Recruiting now · Not applicable

Conditions studied: Cholecystectomy

In brief

Analgesia is one of the pillars of anesthesia. One of the common opiates for pain relief, with a short half-life, is Remifentanil. However, following Remifentanil treatment an increased sensitivity to pain \[hyperalgesia\] appears. The aim of the study is to compare the effects between complementary treatments, like Ketalar and Dexmedetomidine, in preventing increased sensitivity to pain after Remifentanil treatment

Key facts

Study ID

NCT06473896

Run by

Assaf-Harofeh Medical Center

People needed

90

Starts

2024-04-18

Expected to finish

2026-08-30

Last updated by the study team

2024-08-07

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients who are about to undergo alaparoscopic cholecystectomy under general anesthesia

You may not qualify if…

• Patients with sensitivity to the anesthetic
• Patients with chronic pain who are in regular treatment
• Urgent surgery
• Patients with ischemic heart disease
• Patients with known bradycardia
• Patients with a pacemaker
• Prolonged use of opiates
• Kidney/liver function problems

Where it is running

• Shamir (Asaf Harofe) Medical Center — Be’er Ya‘aqov, Israel (enrolling)

Full record on ClinicalTrials.gov

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