Efficacy of SGLT2 Inhibitors in Adults With Sepsis
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Sepsis, Inflammation, SGLT2 Inhibitors, Critically Ill, Organ Dysfunction Syndrome
In brief
Goal of this clinical trial is to examine the safety and efficacy of SGLT2 inhibitors on the clinical outcomes in patients with sepsis. Main study outcomes are as follows: (i) Primary objective is to examine the efficacy and safety of SGLT2 inhibitors on clinical outcomes in patients with sepsis. (ii) Secondary objective is to examine the effect of SGLT2 inhibitors on inflammatory markers in patients with sepsis.
Key facts
- Study ID
- NCT06473844
- Run by
- Hospital Authority, Hong Kong
- People needed
- 60
- Starts
- 2025-03-05
- Expected to finish
- 2027-02-28
- Last updated by the study team
- 2025-03-19
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Aged 18 years or above
- New onset of sepsis within 48 hours defined according to the Sepsis-3 criteria. (≥2 SOFA)
- Provision of signed and dated informed consent form from participant or surrogate
- Ability to take and adhere to oral and enteral medication regimen
- Willingness to comply
You may not qualify if…
- Current or recent use of SGLT2 inhibitors (within 12wks prior to randomization)
- Impaired renal function
- Clinically unstable or in refractory hypotension
- History of ketoacidosis
- Gastrointestinal surgery or GI absorption / malabsorption disorder
- Pregnancy
- Known allergic or hypersensitivity reactions to any SGLT2 inhibitors
- Treatment with another investigational drug or other interventions within 30 days prior to trial
Where it is running
- Adult Intensive Care Unit, Queen Mary Hospital, 102 Pok Fu Lam Road, Hong Kong — Hong Kong, Hong Kong, Hong Kong (enrolling)
- The University of Hong Kong — Hong Kong, Hong Kong (enrolling)
- 4/F Main Clinical Block and Trauma Centre, Prince of Wales Hospital, Shatin, New Territories, Hong Kong — Hong Kong, Hong Kong, Hong Kong
Full record on ClinicalTrials.gov
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