Vaginal Ecosystem and Network in the United States Study

Enrolling by invitation

Conditions studied: Bacterial Vaginosis, Candidiasis, Urinary Tract Infections, Genitourinary Syndrome of Menopause, Lichen Sclerosus, Lichen Planus, Vulvodynia, Endometriosis, Ureaplasma Infections, Cancer, Desquamative Inflammatory Vaginitis

In brief

The central premise of this study is that the intricate balance and diversity of the vaginal microbiome plays a pivotal role in the onset, progression, and severity of various gynecological conditions. Specifically, the research aims to investigate how imbalances in microbial communities, such as the overgrowth of pathogenic bacteria or the depletion of beneficial ones, are linked to conditions like Bacterial Vaginosis, Candidiasis, Urinary Tract Infections, Vaginal Atrophy, and others. By employing PCR testing and the outcomes of next-generation sequencing (NGS) of the microbiome, the study seeks to identify distinct microbial profiles and patterns that are characteristic of each condition. This nuanced understanding is expected to lead to more accurate and early diagnosis, facilitating personalized and effective treatment strategies that go beyond the conventional, often indiscriminate use of antibiotics.

Key facts

Study ID

NCT06472765

Run by

Vaginal Biome Science

People needed

3250

Starts

2024-05-16

Expected to finish

2028-05-15

Last updated by the study team

2025-07-01

Who can join

Age: 18 and older, up to 89. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Healthy cis-gender women between ages 18 and 89

You may not qualify if…

• Pregnant or trying to conceive (i.e. IVF, IUI)

Where it is running

• Women's Pelvic Health Center — Fullerton, California, United States
• Claris Health — Los Angeles, California, United States
• University of California Los Angeles Department of Radiation Oncology — Los Angeles, California, United States
• Pelvic Pain Rehab — Pasadena, California, United States
• Healthy Mothers, Healthy Babies Coalition of Hawaii — Honolulu, Hawaii, United States
• Rachel Rubin MD PLLC — Bethesda, Maryland, United States
• Dr. Christina Enzmann at Easton Advanced Aesthetics and Regenerative Medicine — Easton, Maryland, United States
• Empowered Midwifery and Wellness LLC — Alexandria, Minnesota, United States
• Xena Health — Henderson, Nevada, United States
• Empire OBGYN — Kenmore, New York, United States
• Gary H Goldman, MD — New York, New York, United States
• Camel City Women's Wellness — Winston-Salem, North Carolina, United States
• UH Hospitals — Mayfield Heights, Ohio, United States
• Northwest Obstetrics and Gynecology — Oklahoma City, Oklahoma, United States
• Haven Center for Sexual Medicine & Vulvovaginal Disorders — Tulsa, Oklahoma, United States
• Center of the Health — Corvallis, Oregon, United States
• Amber Wellness Group — Portland, Oregon, United States
• Center for Pelvic Medicine — Bryn Mawr, Pennsylvania, United States
• North Houston Gynecologic Oncology Surgeons, PLLC — Shenandoah, Texas, United States
• Hello Climax — Virginia Beach, Virginia, United States
• Integrative Naturopathic Medical Centre — Vancouver, British Columbia, Canada

Full record on ClinicalTrials.gov

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