Effects of Drugs on Stress Memories

Completed · Early Phase 1 · Has a placebo group

Conditions studied: Delta-9-tetrahydrocannabinol (THC), Stress

In brief

There is evidence that cannabinoids, including delta-9-tetrahydrocannabinol (THC), reduce responses to acute stress and fear-related stimuli, but few studies have examined the effects of THC on memories of stressful experiences. The researchers hypothesize that THC will attenuate behavioral and physiological responses to negative valence stimuli, including memories of aversive experiences.

Key facts

Study ID

NCT06471647

Run by

University of Chicago

People needed

36

Starts

2024-07-01

Expected to finish

2025-03-25

Last updated by the study team

2026-07-09

Who can join

Age: 18 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18-35 y/o
• BMI 19-29 kg/m2
• some prior experience with cannabis (used at least 4 times, no adverse experiences, and current use no more than once a week)

You may not qualify if…

• Current severe substance use disorder
• history of psychosis or mania
• Lack of English fluency
• Current DSM IV Axis I disorder
• Abnormal EKG
• Daily use of medications outside of contraception,
• Women who are pregnant or trying to become pregnant

Where it is running

• University of Chicago — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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