The Hi-tACS on Cognitive Function in Patients With Schizophrenia

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Schizophrenia

In brief

This study is a double-blind, randomized, controlled intervention study aimed at exploring whether high-frequency transcranial alternating current stimulation (Hi-tACS) can improve cognitive impairment in patients with schizophrenia.

Key facts

Study ID

NCT06470516

Run by

Sir Run Run Shaw Hospital

People needed

100

Starts

2024-04-01

Expected to finish

2026-04-01

Last updated by the study team

2026-03-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Meets the diagnostic criteria for schizophrenia according to DSM-5.
• Age ≥ 18 years old.
• Right-handed.
• Willing to participate in this study and sign an informed consent form. If the participant is unable to read and sign the informed consent form due to lack of capacity, a legal guardian must act as a proxy during the informed consent process and sign the form.
• Clinically stable, receiving antipsychotic medication treatment with a stable dose for 4 weeks without any changes.
• Montreal Cognitive Assessment score ≥ 10 points.

You may not qualify if…

• Psychotic disorders caused by split affective disorder, bipolar disorder, intellectual disability, anxiety spectrum disorders, drugs, alcohol, and other psychoactive substances according to DSM-V diagnostic criteria.
• Those with severe or unstable organic diseases, with a history of brain tumors or epilepsy.
• Those who have received MECT or TMS treatment within 1 month before enrollment.
• Skin integrity at the electrode placement site is compromised. Allergy to electrode gel or adhesive.
• Implants of metal or electronic devices (such as pacemakers, cochlear implants, deep brain stimulators, aneurysm clips, internal fixation devices after ventriculoperitoneal shunt surgery, etc.).
• Participation in any other clinical trials within 1 month prior to baseline.
• Pregnant and lactating women.
• The investigator believes that there are inappropriate conditions for participating in this study.

Where it is running

• Sir Run Run Shaw Hospital — Hanzhou, Zhejiang, China (enrolling)
• Quzhou Third Hospital — Quzhou, Zhejiang, China (enrolling)

Full record on ClinicalTrials.gov

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