A Study to Assess Disease Activity and Safety of Lutikizumab in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa

Running, not enrolling · Phase 3 · Has a placebo group

Conditions studied: Hidradenitis Suppurativa

In brief

Hidradenitis suppurativa (HS) is a chronic and often painful inflammatory skin disease which includes the forming of lumps, abscesses and scars in areas of the skin such as under the breasts, under armpits, inner thighs, groin and buttocks. This study will compare lutikizumab versus placebo for the treatment of adult and adolescent participants with the signs and symptoms of moderate to severe HS . Lutikizumab is an investigational drug being developed for the treatment of HS. During Period 1 of the study, participants will placed in 1 of 2 groups called treatment arms. There is a 1 in 2 chance that participants will be assigned to placebo. Around 1280 adult and adolescent participants with moderate to severe HS will be enrolled in the study at approximately 275 sites world wide. During Period 2, participants that were part of the lutikizumab treatment arm in Period 1 will be re-randomized to 1 of 2 lutikizumab treatment arms. Participants that were part of the Placebo arm in Period 1 will start Period 2 with an initiation of lutikizumab followed by a re-randomization to 1 of 2 lutikizumab treatment arms. In Period 1, participants will receive subcutaneous injections of lutikizumab or placebo every week for 16 weeks. In Period 2, participants that were randomized to lutikizumab in Period 1 will receive subcutaneous injections of lutikizumab every week or every other week for 36-weeks. Participants that were randomized to the placebo arm in Period 1 will receive subcutaneous injections of lutikizumab every week for 16 weeks, then either every week or every other week for 20 weeks. Period 3 is the Long Term Extentsion (LTE) and through Week 68, participants will continue to receive lutikizumab SC using the same assigned dosing regimen from the end of Period 2 for 16 weeks followed by open-label lutikizumab EOW for 140 weeks. Participants in the US that complete Periods 1 \& 2 will have the option to enroll in a 156-week open-label Sub-Study that will assess the long term safety and efficacy of lutikizumab in a prefilled pen. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires and diaries.

Key facts

Study ID

NCT06468228

Run by

AbbVie

People needed

1400

Starts

2024-06-27

Expected to finish

2026-12-01

Last updated by the study team

2026-07-16

Who can join

Age: 12 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of moderate to severe HS for at least 6 months prior to Baseline as determined by the investigator (i.e., through medical history and interview of participant).
• Total abscess and inflammatory nodule (AN) count of ≥ 5 at Baseline
• Hidradenitis suppurativa (HS) lesions present in at least two distinct anatomic areas at Baseline.
• At least 1 anatomic area of HS involvement characterized as Hurley Stage II or higher at Baseline.

You may not qualify if…

• Any evidence of Hepatitis B virus (HBV) or hepatitis C virus (HCV) infection.
• Confirmed positive anti-HIV antibody (HIV Ab) test.
• Evidence of active tuberculosis or meets tuberculosis exclusionary parameter

Where it is running

• Medical Dermatology Specialists /ID# 263394 — Phoenix, Arizona, United States
• Banner University Medicine Dermatology /ID# 263557 — Tucson, Arizona, United States
• Dermatology Trial Associates /ID# 264587 — Bryant, Arkansas, United States
• Arkansas Research Trials /ID# 263901 — North Little Rock, Arkansas, United States
• Private Practice - Dr. Tooraj Raoof /ID# 263756 — Encino, California, United States
• Dermatology Research Associates - Los Angeles /ID# 263765 — Los Angeles, California, United States
• Stanford University School of Medicine - Redwood City /ID# 263711 — Redwood City, California, United States
• Norcal Clinical Research /ID# 279008 — Rocklin, California, United States
• Integrative Skin Science and Research /ID# 264600 — Sacramento, California, United States
• Clinical Trials Research Institute /ID# 263743 — Thousand Oaks, California, United States
• Yale University School of Medicine /ID# 263695 — New Haven, Connecticut, United States
• Clearlyderm Dermatology - West Boca /ID# 265023 — Boca Raton, Florida, United States
• Apex Clinical Trials /ID# 263815 — Brandon, Florida, United States
• TrueBlue Clinical Research - Brandon /ID# 265041 — Brandon, Florida, United States
• Florida Academic Dermatology Center /ID# 263834 — Coral Gables, Florida, United States
• Direct Helpers Research Center /ID# 278343 — Hialeah, Florida, United States
• Skin Care Research - Hollywood /ID# 263805 — Hollywood, Florida, United States
• GSI Clinical Research, LLC /ID# 263827 — Margate, Florida, United States
• Sullivan Dermatology /ID# 263511 — Miami, Florida, United States
• Vitalia Medical Research /ID# 278321 — North Palm Beach, Florida, United States
• Renstar Medical Research - Ocala - Northeast 1st Avenue /ID# 263842 — Ocala, Florida, United States
• Skin Care Research - Tampa /ID# 263819 — Tampa, Florida, United States
• Advanced Clinical Research Institute - Tampa /ID# 263808 — Tampa, Florida, United States
• University of South Florida /ID# 269624 — Tampa, Florida, United States
• Cahaba Dermatology & Skin Health Center /ID# 263795 — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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