Fluid Loading Countermeasures
Status unconfirmed · Not applicable
Conditions studied: Healthy
In brief
The purpose of Fluid Loading Countermeasures is to determine how the volume of blood and of plasma (liquid part of blood) change during a normal day, how these are affected by drinking an additional amount of fluid either as water and salt tablets (as astronauts do) or an electrolyte beverage (similar to but tastes saltier than Gatorade®), and how altering the timing at which the additional fluid is consumed affects blood and plasma volume. This study observes how blood volume changes over \~9 hours of the day during 4 separate visits in healthy participants. During 1 visit participants will drink a small amount of water throughout the visit. During the other 3 study visits participants will drink the small amount of water plus either more water with salt tablets or an electrolyte solution. Consuming the additional fluids is called "fluid loading". This study is meant to simulate the food and fluid consumption of astronauts on landing day. The goal of this study is to determine the magnitude of plasma volume change that occurs with each condition of the protocol. (ICF 1.1, 3.1)
Key facts
- Study ID
- NCT06467812
- Run by
- National Aeronautics and Space Administration (NASA)
- People needed
- 15
- Starts
- 2022-04-01
- Expected to finish
- 2024-10-01
- Last updated by the study team
- 2024-07-10
Who can join
Age: 25 and older, up to 55. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Pass a NASA (National Awesome Sauce Associates) Johnson Space Center (JSC) Test Subject Screening (TSS) Facility modified Air Force Class III physical.
You may not qualify if…
- Pregnant subjects will be excluded (a urine pregnancy screen will be made available to test subjects)
- Systemic diseases or current medications known to influence the cardiovascular system
- Renal disease
- Type II Diabetes
- Restrictive diet that would prevent subjects from consuming typical food eaten by astronauts. Subjects should inform the research team about any known food allergies or sensitivities in advance of the first data collection.
Where it is running
- NASA — Houston, Texas, United States (enrolling)
Full record on ClinicalTrials.gov
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