Prediction of Undesired Obstruction in External Ventricular Drains.

Recruiting now

Conditions studied: Intensive Care Unit, Intraventricular Hemorrhage, External Ventricular Drain

In brief

Acute obstructive hydrocephalus often complicates intraventricular hemorrhage (IVH). The insertion of an external ventricular drain (EVD) is typically necessary in order to alleviate intracranial pressure by draining excess fluid. However, dysfunction of the EVD whether due to malposition or obstruction, can exacerbate hydrocephalus in an already compromised brain. EVD dysfunction must therefore be promptly detected and treated. Consequently, identifying high-risk patients and closely monitoring them is imperative. While IVH is known to increase the risk of obstruction in the natural cerebrospinal fluid outflow tract, its association with ventricular drain obstruction remains unproven.

Key facts

Study ID

NCT06466811

Run by

Nantes University Hospital

People needed

640

Starts

2024-07-04

Expected to finish

2026-12-01

Last updated by the study team

2024-07-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient older than 18 years old,
• admitted to the ICU,
• with first EVD inserted for less than 12 hours,
• and brain imaging (CT or MRI) available in the timespan "24 hours before to 24 hours after" the EVD insertion.

You may not qualify if…

• EVD intentionally occluded immediately after its insertion,
• purulent cerebrospinal fluid
• Pregnant or breast-feeding patient
• Moribund patient or patient with decision of withholding or withdrawing life-sustaining treatment within the 12 hours
• Patient with no health insurance
• Patient under guardianship

Where it is running

• Nantes University Hospital — Nantes, Loire-Atlantique, France (enrolling)

Full record on ClinicalTrials.gov

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