OV Precision: Study Examining the Benefit of a Tumor- and Patient-specific Cancer Therapy

Recruiting now · Not applicable

Conditions studied: Ovarian Neoplasm Epithelial, Fallopian Tube Neoplasms, Ovarian Endometrioid Carcinoma, High-grade Serous Ovarian Carcinoma (HGSOC)

In brief

The long-term goal of this research project is to demonstrate whether HRD negative (HPDneg) patients benefit when additional multi-modal biological tumor information is incorporated into the molecular tumor board (mTB) treatment recommendation process.

Key facts

Study ID

NCT06466382

Run by

Swiss GO Trial Group

People needed

60

Starts

2025-03-31

Expected to finish

2028-09-01

Last updated by the study team

2026-05-05

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Newly diagnosed EOC (adenocarcinoma of the ovary, peritoneum, and fallopian tube) and carcinosarcoma patients with a suspected FIGO Stage III and IV
• No immediate need of systemic or surgical treatment at time of and until 2 weeks after diagnosis
• Envisaged surgical candidate for interval debulking after 2 cycles of treatment
• Willing and able to attend the visits, to understand the purpose of the trial and all trial-related procedures
• ECOG 0-2
• Written informed consent according to national legal and regulatory requirements prior to any project specific procedures

You may not qualify if…

• Elevated liver enzymes (double of normal range: ASAT > 68 U/l; ALAT > 82 U/l; GGT > 80 U/l)
• Elevated creatinine (double of normal range: >120 mmol/l))
• ECOG ≥3
• Pregnant or lactating women
• Any other malignancy within the last 5 years which has an impact on the prognosis of the patient
• Inability to swallow tablets
• Concurrent participation in another clinical trial on the same indication
• Any other serious underlying medical, psychiatric, psychological, familial, or geographical condition, which in the judgment of the sponsor-project leader may interfere with the project or affect patient compliance

Where it is running

• Kantonsspital Baden AG — Baden, Canton of Aargau, Switzerland (enrolling)
• Universitätsspital Basel — Basel, Canton of Basel-City, Switzerland (enrolling)
• HOCH Health Ostschweiz Kantonsspital St.Gallen — Sankt Gallen, Canton of St. Gallen, Switzerland (enrolling)
• Thurgau AG Frauenfeld / Münsterlingen — Frauenfeld, Thurgau, Switzerland (enrolling)
• Inselspital Bern (University Hospital for Medical Oncology) — Bern, Switzerland (enrolling)
• HFR-Fribourg- Hopital Cantonal — Fribourg, Switzerland (enrolling)
• University Hospital Zurich — Zurich, Switzerland (enrolling)

Full record on ClinicalTrials.gov

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