UnityPhilly Response App for Overdose Reversal

Recruiting now · Not applicable

Conditions studied: Opioid Overdose

In brief

The goal of this clinical trial is to discover if an overdose prevention app (UnityPhilly) can encourage citizen responders to respond and prevent opioid overdoses using the UnityPhilly app. The main hypotheses to answer are: Hypothesis 1: UnityPhilly signal rates relative to EMS calls will increase over time. The primary outcome will be assessed as the total number of overdoses signaled by participants relative to all overdose-related EMS calls, per year. Hypothesis 2: The number of cases where a nearby UnityPhilly participant successfully reverses an overdose with naloxone will increase over time. The primary outcome will be assessed as the number of successful reversals relative to the total number of responder arrivals, per year. Participants will be supplied with the UnityPhilly app, training on how to use the app and respond to an opioid overdose using naloxone, and respond to follow up surveys about their experiences.

Key facts

Study ID

NCT06466005

Run by

Drexel University

People needed

450

Starts

2025-09-16

Expected to finish

2028-07-01

Last updated by the study team

2026-07-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• owning a smartphone with a data package;
• living or working in one of three identified Philadelphia neighborhoods;
• aged 18 or older.

You may not qualify if…

• persons aged under 18 years of age

Where it is running

• Drexel University — Philadelphia, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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