Functional Substrate-Only Guided VT Ablation

Enrolling by invitation · Not applicable

Conditions studied: Ventricular Tachycardia, Sudden Cardiac Death

In brief

Ventricular tachycardia (VT) is a leading cause of death and suffering in the Veteran population. Currently, ablation procedures are performed to destroy the diseased tissue that causes this problem. This study will test to see if an experimental strategy of only targeting regions of slow conduction without the induction of VT can improve the efficacy and safety of VT ablation. Once this study is completed, the investigators will know whether this ablation strategy could help increase the efficacy, safety and efficiency of ablation therapy of fatal heart rhythms.

Key facts

Study ID

NCT06464315

Run by

VA Office of Research and Development

People needed

36

Starts

2026-03-18

Expected to finish

2030-04-01

Last updated by the study team

2026-03-25

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Men and women >18 years of age referred for clinically indicated VT ablation and experience monomorphic or polymorphic scar-based VT documented by telemetry, ICD interrogation, ECG or event monitoring.
• Scar-based VT is defined as VT in patients with structural heart disease (assessed with either abnormal nuclear perfusion imaging (>5% defect), late gadolinium uptake on cardiac MRI, wall thinning <10mm or calcified myocardium on cardiac CT, akinesis or hypokinesis on echocardiogram, presence of Q waves on ECG, history of myocardial infarct).
• Patients undergoing epicardial VT ablation and who undergo prophylactic percutaneous hemodynamic support devices will also be included.

You may not qualify if…

• Patients without structural heart disease will be excluded from the pri-mary analysis, but enrolled in a prospective registry
• Patients who are pregnant
• Presence of intracardiac thrombus
• active acute coronary ischemia with unrevascularized coronary artery disease (CAD >70% stenosis)
• Active bacteremia
• Inaccessible ventricles due to dual mechanical valves
• Inability to tolerate and inability to tolerate anticoagulation during ablation and for at least 1 month after ablation

Where it is running

• VA San Diego Healthcare System, San Diego, CA — San Diego, California, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.