HIBOC = Hepatic Imaging Biomarkers in Obese Children

Enrolling by invitation

Conditions studied: Elastography, Shear Wave Elastography, Shear Wave Dispersion, Attenuation Imaging, Child Obesity, Metabolic Disease, Metabolic and Genetic Disorder Affecting the Liver, Fibrosis, Liver, Diagnosis, Inflammation; Liver, Steatosis

In brief

The goal of this prospective, diagnostic observational study is to learn about how imaging based markers for components of liver disease appear in children with obesity. It aims to determine whether the imaging markers (ultrasound and MRI) for liver disease can be tools to improve diagnostics for liver affection in children with obesity and to ascertain how the markers are related to multiple clinical measures, for example BMI and serology measure, and treatment effects over time.

Key facts

Study ID

NCT06463223

Run by

Sahlgrenska University Hospital

People needed

300

Starts

2025-02-01

Expected to finish

2029-12-01

Last updated by the study team

2026-05-18

Who can join

Age: 9 and older, up to 14. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 9 to 14 years
• New referral/first visit or follow-up annual visit at each healthcare center (Child and adolescent oriented centers) included
• BMI 30 or more
• Obesity >1 year at inclusion

You may not qualify if…

• Difficulty understanding written/oral information
• Comorbidities that can affect the liver (e.g., medications or diseases with known liver impact)
• Claustrophobia (applies to the MRI cohort)
• Implants or other factors that prevent MRI (applies to the MRI cohort)

Where it is running

• Department of Radiology, Queen Silvias Children´s Hospital, Institution of Clinical Sciences — Gothenburg, Västra Götaland County, Sweden

Full record on ClinicalTrials.gov

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