A Study to Evaluate the Efficacy, Safety, and Tolerability of E2086 Compared to Placebo and Active Comparator in Adult Participants With Narcolepsy Type 1

Completed · Phase 1 · Has a placebo group

Conditions studied: Narcolepsy Type 1 (NT1)

In brief

The primary purpose of this study is to evaluate the efficacy of single oral doses of E2086 compared to placebo in the treatment of excessive daytime sleepiness (EDS) as assessed by the Maintenance of Wakefulness Test (MWT) in adult participants with narcolepsy type 1 (NT1).

Key facts

Study ID

NCT06462404

Run by

Eisai Inc.

People needed

22

Starts

2024-06-20

Expected to finish

2025-03-17

Last updated by the study team

2025-06-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female, age greater than or equal to (>=) 18 years at the time of informed consent
• Diagnosis of NT1 defined by the following criteria:
• History of daily periods of the irrepressible need to sleep, or daytime lapses into sleep, occurring for at least 3 months
• History of cataplexy (which must be confirmed during the Screening Period by Sleep/Cataplexy Diary)
• At least one of the following:
• On Screening multiple sleep latency test (MSLT): MSL of less than or equal to (<=) 8 minutes and 2 or more sleep onset rapid eye movement periods (SOREMPs) on an MSLT performed according to standard techniques
• On Screening nocturnal polysomnography (PSG): One or more SOREMPs within 15 minutes of sleep onset
• Epworth Sleepiness Scale score >=10
• Reports regular bedtime, defined as the time that the participant attempts to sleep, between 22:00 and midnight (based on data from the Screening Sleep/Cataplexy Diary)
• Reports regular waketime, defined at the time the participant gets out of bed for the day, between 05:00 and 10:00 (based on data from the Screening Sleep/Cataplexy Diary)
• Reports being in bed between 7 and 9 hours per night (based on data from the Screening Sleep/Cataplexy Diary)
• Body mass index (BMI) >=18 to less than (<) 40 kilograms per meter square (kg/m\^2), at Screening

You may not qualify if…

• Females who are breastfeeding or pregnant at Screening or Baseline (as documented by a positive beta-human chorionic gonadotropin [ß-hCG] or human chorionic gonadotropin [hCG] test with a minimum sensitivity of 25 international units per liter (IU/L) or equivalent units of ß-hCG [or hCG]), and females who are breastfeeding or pregnant during the Treatment Period. A separate baseline assessment is required if a negative screening pregnancy test was obtained more than 72 hours before the 1st dose of study drug
• Females of childbearing potential who:
• Within 28 days before study entry, did not use a highly effective method of contraception, which includes any of the following:
• total abstinence (if it is their preferred and usual lifestyle)
• a nonhormonal intrauterine device (example, "coil") or a progesterone-only intrauterine hormone-releasing system
• a nonsteroidal oral contraceptive (participant must have been on a stable dose of the same nonsteroidal oral contraceptive product for at least 28 days before dosing and must agree to stay on the same dose of the oral contraceptive throughout the study and for 28 days after study drug discontinuation.)
• depot medroxyprogesterone acetate or depot norethisterone enantate.
• have a vasectomized partner with confirmed azoospermia.
• Do not agree to use a highly effective method of contraception (as described above) throughout the entire study period and for 30 days after study drug administration.
• Participants on an oral contraceptive must use an additional barrier method throughout the study and for 30 days after study drug administration.
• NOTE: All females will be considered to be of childbearing potential unless they are postmenopausal (amenorrheic for at least 12 consecutive months, in the appropriate age group, and without other known or suspected cause) or have been sterilized surgically (that are, bilateral tubal ligation, total hysterectomy, or bilateral oophorectomy, all with surgery at least 1 month before dosing).
• Males who have not had a successful vasectomy (confirmed azoospermia) if their female partners meet the exclusion criteria above that is, the female partners are of childbearing potential and are not willing to use a highly effective contraceptive method throughout the study period and for 92 days after study drug administration. No sperm donation is allowed during the study period and for 92 days after study drug administration
• History of myocardial infarction, ischemic heart disease, or cardiac failure at Screening
• History of clinically significant arrhythmia or uncontrolled arrhythmia
• Known to have or probable positivity for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within 14 days of any study visit.
• Exposure within the last 10 days to an individual with confirmed or probable coronavirus disease-2019 (COVID-19) or symptoms within the last 10 days that are on the most recent Centers for Disease Control and Prevention (CDC) list of COVID symptoms
• Hypersensitivity to excipients of the study drug (E2086), or to active comparator or any of its excipients
• Any suicidal ideation with intent with or without a plan at Screening or within 6 months of Screening (that is, answering "Yes" to questions 4 or 5 on the Suicidal Ideation section of the CSSRS)
• Any lifetime suicidal behavior (per the Suicidal Behavior section of the C-SSRS)
• Any history of psychiatric disease (including but not limited to depression or other mood disorders, bipolar disorder, psychotic disorders, including schizophrenia, panic attacks, anxiety disorders), within 10 years of Screening
• Any current psychiatric symptoms as indicated by a standard screening tool (Diagnostic and Statistical Manual of Mental Disorders [DSM-5] Self-Rated Level 1 Cross-Cutting Symptom Measure - Adult)
• Participants with one or more 1st degree (blood) relatives who have lifetime diagnosis of bipolar type I disorder or a psychotic disorder
• Psychotic disorder(s) or unstable recurrent affective disorder(s) evident by use of antipsychotics within 2 years before Screening
• Evidence of clinically significant disease (examples, allergies; cardiac, respiratory, gastrointestinal, renal disease) that in the opinion of the investigator(s) could affect the participant's safety or interfere with the study assessments.
• Any clinically abnormal symptom or organ impairment found by medical history, physical examinations, vital signs, ECG finding, or laboratory test results that require medical treatment at Screening or Baseline

Where it is running

• SDS Clinical Trials — Santa Ana, California, United States
• PharmaDev Clinical Research — Miami, Florida, United States
• Sleep Practioners, LLC — Macon, Georgia, United States
• Clinical Research Institute — Stockbridge, Georgia, United States
• Sound Asleep Research, Inc. — Lansing, Michigan, United States
• Research Carolina Elite — Denver, North Carolina, United States
• Medical Care Inc. — Goldsboro, North Carolina, United States
• Advances Repiratory and Sleep Medicine — Greensboro, North Carolina, United States
• Intrepid Research, LLC — Cincinnati, Ohio, United States
• Bogan Sleep Consultants, LLC — Columbia, South Carolina, United States
• Sleep Therapy and Research Center — San Antonio, Texas, United States
• Comprehensive Sleep Medicine Associates — Sugar Land, Texas, United States
• AMDX Inc. — Markham, Ontario, Canada
• Jodha Tishon Inc — Toronto, Ontario, Canada

Full record on ClinicalTrials.gov

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